Identification and characterization of PKCg, a kinase associated with SCA14, as an amyloidogenic protein
نویسندگان
چکیده
Biosignal Research Center, Kobe University, Kobe 657-8501, Japan, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK, Department of Neurophysiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan, Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan and Department of Molecular and Pharmacological Neuroscience, Graduate School ofBiomedical Science, HiroshimaUniversity, Hiroshima 734-8551, Japan
منابع مشابه
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.
Amyloid assemblies are associated with a wide range of human disorders, including Alzheimer's and Parkinson's diseases. Here, we identify protein kinase C (PKC) γ, a serine/threonine kinase mutated in the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14), as a novel amyloidogenic protein with no previously characterized amyloid-prone domains. We found that overexpression of PKCγ ...
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